Carmofur
货号：
14243-100mg 基本售价：
350.0 元 规格：
100 mg
产品信息
概述| 货号 | 14243-100mg |
| 描述 | Carmofur is a fluorinated pyrimidine and derivative of fluorouracil (Item No. 14416). It has anti-neoplastic activity and is commonly used as adjuvant therapy following resection for some forms of cancer.1 Recent studies have shown that carmofur is a potent inhibitor of acid ceramidase (IC50 = 29 nM), an enzyme that is over-expressed in some tumors.2,3 |
| 别名 | HCFU; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sakamoto, J.,Hamada, C.,Rahman, M., et al. An individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer. Japanese Journal of Clinical Oncology 35(9), 536-544 (2015).
2.Realini, N.,Solorzano, C.,Pagliuca, C., et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci.Rep. 3(1035), 1-7 (2013).
3.Pizzirani, D.,Pagliuca, C.,Realini, N., et al. Discovery of a new class of highly potent inhibitors of acid ceramidase: Synthesis and structure-activity relationship (SAR). Journal of Medicinal Chemistry 56(9), 3518-3530 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 257.3 |
| 分子式 | C11H16FN3O3 |
| CAS号 | 61422-45-5 |
| 稳定性 | ≥ 2 years |
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