Bioymifi
货号：
14242-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14242-1mg |
| 描述 | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TNF-related apoptosis-inducing ligand (TRAIL or Apo2L), a member of this family, activates apoptosis in a variety of tumor cell lines by signaling through the death receptors, DR4 and DR5. Bioymifi directly activates DR5 (Kd = 1.2 µM; IC50 = 2 µM), inducing DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, G.,Wang, X.,Yu, H., et al. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nature Chemical Biology 9, 84-90 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 494.3 |
| 分子式 | C22H12BrN3O4S |
| CAS号 | 1420071-30-2 |
| 稳定性 | ≥ 2 years |
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