EBPC
货号：
14183-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14183-1mg |
| 描述 | The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF2α synthase in response to interleukin-1β.1 Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs.2 EBPC is a potent, selective inhibitor of aldose reductase with an IC50 value of 47 nM in vitro.3 Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells.2 EBPC also inhibits prostaglandin F2α(PGF2α) and PGE2 production in human endometrial cells with an EC50 value of 10 μM.1 |
| 别名 | NSC 229530; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bresson, E.,Lacroix-Pépin, N.,Boucher-Kovalik, S., et al. The prostaglandin F synthase activity of the human aldose reductase AKR1B1 brings new lenses to look at pathologic conditions. Front.Pharmacol. 3(98), (2012).
2.Lee, E.K.,Regenold, W.T. and Shapiro, P. Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-Cancer Drugs 13(8), 859-868 (2002).
3.Mylari, B.L.,Beyer, T.A. and Siegel, T.W. A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. Journal of Medicinal Chemistry 34, 1011-1018 (1991).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 261.3 |
| 分子式 | C14H15NO4 |
| CAS号 | 4450-98-0 |
| 稳定性 | ≥ 2 years |
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