| 货号 | 14179-10mg |
| 描述 | Voglibose is a competitive α-glucosidase inhibitor (IC50 = 5.6 µM) that was first isolated from S. hygroscopicus.1,2 It has been shown to delay the absorption and digestion of dietary polysaccharides by reversibly inhibiting digestive enzymes such as maltase, isomaltase, and sucrase with IC50 values of 0.18, 5.2, and 0.37 µM, respectively.2,3 Voglibose is also reported to increase glucagon-like peptide 1 release.4,5 In clinical trials, voglibose has been used to inhibit postprandial hyperglycemia associated with diabetes without cardiovascular complications.1,6 |
| 别名 | AO-128; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dabhi, A.S.,Bhatt, N.R. and Shah, M.J. Voglibose: An alpha glucosidase inhibitor. J.Clin.Diagn.Res. 7(12), 3023-3027 (2013). 2.Kuriyama, C.,Kamiyama, O.,Ikeda, K., et al. In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorganic & Medicinal Chemistry 16(15), 7330-7336 (2008). 3.Natori, Y.,Imahori, T.,Murakami, K., et al. The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters 21(2), 738-741 (2011). 4.Göke, B.,Fuder, H.,Wieckhorst, G., et al. Voglibose (AO-128) is an efficient α-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve. Digestion 56(6), 493-501 (2016). 5.Nauck, M.A.,Vardarli, I.,Deacon, C.F., et al. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down? Diabetologia 54(1), 10-18 (2011). 6.Standl, E. and Schnell, O. Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation. Diab.Vasc.Dis.Res. 9(3), 163-169 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 267.3 |
| 分子式 | C10H21NO7 |
| CAS号 | 83480-29-9 |
| 稳定性 | ≥ 2 years |
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