| 货号 | 14173-1g |
| 描述 | Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM).1,2 At 100 mg/kg/day, naringenin selectively inhibits the transcription of Smad3 and directly down-regulates TGF-β1, significantly reducing lung metastasis in mice with bleomycin-induced pulmonary fibrosis.3 Naringenin demonstrates both lipid lowering and insulin-like properties in low-density lipoprotein (LDL) receptor-deficient mice fed a Western diet containing 1-3% naringenin by correcting VLDL overproduction, ameliorating hepatic steatosis, and attenuating dyslipidemia without affecting caloric intake or fat absorption.4 |
| 别名 | S-Dihydrogenistein;NSC 11855;NSC 34875;Salipurol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fuhr, U.,Klittich, K. and Staib, A.H. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. British Journal of Clinical Pharmacology 35(4), 431-436 (1993). 2.Ho, P.C. and Saville, D.J. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. Journal of Pharmacy & Pharmaceutical Sciences 4(3), 217-227 (2001). 3.Du, G.,Jin, L.,Han, X., et al. Naringenin: A potential immunomodulator for inhibiting lung fibrosis and metastasis. Cancer Research 69, 3205-3212 (2009). 4.Mulvihill, E.E.,Allister, E.M.,Sutherland, B.G., et al. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 58, 2198-2210 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 272.3 |
| 分子式 | C15H12O5 |
| CAS号 | 67604-48-2 |
| 稳定性 | ≥ 2 years |
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