| 货号 | 14152-1g |
| 描述 | Quetiapine is an atypical, second generation antipsychotic compound.1,2,3 It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).4,5 Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).5 |
| 别名 | ICI 204636;Seroquel XR®; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Seeman, P. Atypical antipsychotics: Mechanism of action. Can.J.Psychiatry 47(1), 27-38 (2002). 2.Rummel-Kluge, C.,Komossa, K.,Schwarz, S., et al. Second-generation antipsychotic drugs and extrapyramidal side effects: A systematic review and meta-analysis of head-to-head comparisons. Schizophr.Bull. 38(1), 167-177 (2012). 3.Cerejeira, J. and Mukaetova-Ladinska, E.B. A clinical update on delirium: From early recognition to effective management. Nurs.Res.Pract. 2011, (2011). 4.Richelson, E. and Souder, T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sciences 68(1), 29-39 (2000). 5.Kroeze, W.K.,Hufeisen, S.J.,Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 441.5 |
| 分子式 | C21H25N3O2S • 1/2C4H4O4 |
| CAS号 | 111974-72-2 |
| 稳定性 | ≥ 2 years |
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