| 货号 | 14128-5mg |
| 描述 | Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.1,2 Fludarabine is an adenosine deaminase resistant analog of 9-β-D-arabinofuranosyladenine (ara-A) that disrupts ribonucleotide reductase and DNA polymerase in blood cells. It exhibits antiproliferative activity (IC50 = 1.54 μM in an RPMI-8226 myeloma cell line) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP, and survivin expression.3,4 Fludarabine is effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.5,6,7 |
| 别名 | F-ara-A;NSC 118218; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chao, D.L.S. and Kimball, A.P. Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine. Cancer Research 32, 1721-1724 (1972). 2.Tallman, M.S. and Hakimian, D. Purine nucleoside analogs: Emerging roles in indolent lymphoproliferative disorders. Blood 86(7), 2463-2474 (1995). 3.Meng, H.,Yang, C.,Ni, W., et al. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. European Journal of Haematology 79(6), 486-493 (2007). 4.Bellosillo, B.,Villamor, N.,Colomer, D., et al. In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 94(8), 2836-2843 (1999). 5.Spriggs, D.R.,Stopa, E.,Mayer, R.J., et al. Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: Phase I and neuropathological study. Cancer Research 46, 5953-5958 (1986). 6.Tournilhac, O.,Cazin, B.,Leprètre, S., et al. Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood 103(1), 363-365 (2004). 7.Rai, K.R.,Peterson, B.L.,Appelbaum, F.R., et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. New England Journal of Medicine 343(24), 1750-1757 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 285.2 |
| 分子式 | C10H12FN5O4 |
| CAS号 | 21679-14-1 |
| 稳定性 | ≥ 2 years |
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