Diapocynin
货号：
14052-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14052-1mg |
| 描述 | Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin (Item No. 11976) that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in peripheral blood mononuclear cells (PMBCs).1 It inhibits production of reactive oxygen species (ROS), calcium-independent isoform of phospholipase A2(iPLA2) function, and reduces Ca2+ influx through store-operated and stretch-activated channels (SOCs and SACs, respectively) in dystrophic myotubes; all functions in the pathogenic cascade leading to muscular dystrophy.2 Diapocynin also reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinsons disease.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kanegae, M.P.,Condino-Neto, A.,Pedroza, L.A., et al. Diapocynin versus apocynin as pretranscriptional inhibitors of NADPH oxidase and cytokine production by peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 393(3), 551-554 (2010).
2.Ismail, H.M.,Scapozza, L.,Ruegg, U.T., et al. Diapocynin, a dimer of the NADPH oxidase inhibitor apocynin, reduces ROS production and prevents force loss in eccentrically contracting dystrophic muscle. PLoS One 9(10), e110708 (2014).
3.Dranka, B.P.,Gifford, A.N.,Ghosh, A., et al. Diapocynin prevents early Parkinson’s disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse. Neurosci. Lett. 549, 57-62 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 330.3 |
| 分子式 | C18H18O6 |
| CAS号 | 29799-22-2 |
| 稳定性 | ≥ 2 years |
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