| 货号 | 14031-500ug |
| 描述 | Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus.1 It is a protein kinase C activator that displays a Ki value of 30 μM and an ED50 value of 27 μM in vitro.2,3 Most ingenol esters are tumor-promoting.4 However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wender, P.A.,Koehler, K.F.,Sharkey, N.A., et al. Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proceedings of the National Academy of Sciences of the United States of America 83, 4214-4218 (1986). 2.Hasler, C.M.,Acs, G. and Blumberg, P.M. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Research 52(1), 202-208 (1992). 3.Vogg, G.,Mattes, E.,Rothenburger, J., et al. Tumor promoting diterpenes from Euphorbia leuconeura L. Phytochemistry 51(2), 289-295 (1999). 4.Nelson, T.J. and Alkon, D.L. Neuroprotective versus tumorigenic protein kinase C activators. Trends in Biochemical Sciences 34(3), 136-145 (2009). 5.Lebwohl, M.,Swanson, N.,Anderson, L.L., et al. Ingenol mebutate gel for actinic keratosis. New England Journal of Medicine 366(11), 1010-1019 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.4 |
| 分子式 | C20H28O5 |
| CAS号 | 30220-46-3 |
| 稳定性 | ≥ 2 years |
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