| 货号 | 14016-1mg |
| 描述 | Iberin is a natural isothiocyanate found in cruciferous plants.1 When introduced into the daily diet of rats or added to rat hepatocytes (40 μM), it induces the expression of phase II detoxification enzymes, including quinone reductase and glutathione S-transferase.1,2 In addition, iberin activates the nuclear factor E2-related protein Nrf2, which promotes the expression of antioxidant and phase II genes.2,3 Iberin also induces the apoptosis of some cancer cell lines.4,3 Interestingly, iberin also acts as a quorum sensing inhibitor, blocking acyl-homoserine lactone signaling in P. aeruginosa without affecting growth (IC50 = 31-62 μM).5 |
| 别名 | NSC 321801; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Munday, R. and Munday, C.M. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: Comparison of allyl isothiocyanate with sulforaphane and related compounds. Journal of Agricultural and Food Chemistry 52(7), 1867-1871 (2004). 2.La Marca, M.,Beffy, P.,Croce, C.D., et al. Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes. Food and Chemical Toxicology 50(8), 2822-2830 (2012). 3.Barrera, L.N.,Cassidy, A.,Wang, W., et al. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochimica et Biophysica Acta 1823, 1914-1924 (2012). 4.Jadhav, U.,Ezhilarasan, R.,Vaughn, S.F., et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. International Journal of Molecular Medicine 19(3), 353-361 (2007). 5.Jakobsen, T.H.,Bragason, S.K.,Phipps, R.K., et al. Food as a source for quorum sensing inhibitors: Iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Applied and Environmental Microbiology 78(7), 2410-2421 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 163.3 |
| 分子式 | C5H9NOS2 |
| CAS号 | 505-44-2 |
| 稳定性 | ≥ 2 years |
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