| 货号 | 14011-500ug |
| 描述 | Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of PGE2 (Item No. 14010) with enhanced lipid solubility. PGE2 is one of the primary cyclooxygenase products of arachidonic acid (Item No. 90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4 The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.5 Affinity constants (Kd) values of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.5 |
| 别名 | Dinoprostone methyl ester;PGE2 methyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Willis, A.L. and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3, 353-357 (1973). 2.Jackson, G.M.,Sharp, H.T. and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. American Journal of Obstetics and Gynecology 171, 1092-1096 (1994). 3.Robert, A.,Schultz, J.R.,Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70, 359-370 (1976). 4.Arvind, P.,Papavassiliou, E.D.,Tsioulias, G.J., et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34, 5604-5609 (1995). 5.Coleman, R.A.,Smith, W.L. and Narumiya, S. Classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews 46, 205-229 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 366.5 |
| 分子式 | C21H34O5 |
| CAS号 | 31753-17-0 |
| 稳定性 | ≥ 1 year |
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