| 货号 | 13996-1mg |
| 描述 | MDL 72527 is a polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase (IC50s = 6.1 and 0.02 µM, respectively).1 It does not inhibit monoamine oxidase or D-amino acid oxidase. MDL 72527 inhibits PAO-dependent H2O2productionin vitroandin vivo and is used to study the role of PAO activity in diverse models, including infection, cancer, and hyperoxia.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moriya, S.S.,Miura, T.,Takao, K., et al. Development of irreversible inactivators of spermine oxidase and N1-acetylpolyamine oxidase. Biol. Pharm. Bull. 37(3), 475-480 (2014). 2.Chaturvedi, R.,Cheng, Y.,Asim, M., et al. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J. Biol. Chem. 279(38), 40161-40173 (2004). 3.Goodwin, A.C.,Destefano, C.E.,Wu, S., et al. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc. Natl. Acad. Sci. USA 108(37), 15354-15359 (2011). 4.Patel, C.A.,Xu, Z.,Xing, J., et al. Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy. Biochim Biophys. Acta. 1862(9), 1628-1639 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 265.2 |
| 分子式 | C12H20N2 • 2HCl |
| CAS号 | 93565-01-6 |
| 稳定性 | ≥ 2 years |
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