| 货号 | 13974-25mg |
| 描述 | Timolol is a non-selective β-adrenergic receptor antagonist with log Kd values of -8.27, -9.86, and -6.8 for binding to human β1-, β2-, and β3-adrenoceptors, respectively.1 It has been reported that only the (S) enantiomer contributes to the β-blocking effects of racemic timolol, but the weakly active (R) isomer maintains a beneficial effect on intraocular pressure without the undesirable side-effect of bronchial constriction caused by non-selective action of (S)-timolol on β1 and β2receptors.2,3 Timolol has been use alone and in fixed combinations with either prostaglandin analogs or carbonic anhydrase inhibitors to reduce intraocular pressure in research models of ocular hypertension and glaucoma.4,5 |
| 别名 | MK-950;(S)-Timolol (maleate);WP934; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). 2.Tosi, G.,Zironi, F.,Caselli, E., et al. Biocatalytic asymmetric synthesis of 9S)- and (R)-timolol. Synthesis 10, 1625-1628 (2004). 3.Mehvar, R. and Brocks, D.R. Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humans. J. Pharm. Pharm. Sci. 4(2), 185-200 (2001). 4.Cheng, J.W.,Cheng, S.W.,Gao, L.D., et al. Intraocular pressure-lowering effects of commonly used fixed-combination drugs with Timolol: A systematic review and meta-analysis. PLoS One 7(9), 45079 (2012). 5.Li, N.,Chen, X.m.,Zhou, Y., et al. Travoprost compared with other prostaglandin analogues or timolol in patients with open-angle glaucoma or ocular hypertension: Meta-analysis of randomized controlled trials. Clinical & Experimental Ophthalmology 34, 755-764 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 432.5 |
| 分子式 | C13H24N4O3S • C4H4O4 |
| CAS号 | 26921-17-5 |
| 稳定性 | ≥ 2 years |
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