| 货号 | 13951-1mg |
| 描述 | Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.4 IWP-2 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.4 At 5 μM, IWP-2 has been shown to block Wnt-dependent phosphorylation of the frizzled co-receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.4 This compound has been used to suppress embryonic stem cell self-renewal and to decrease cancer cell proliferation, migration, and invasion.5,6 |
| 别名 | Inhibitor of Wnt Production-2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006). 2.Polakis, P. Wnt signaling and cancer. Genes & Development 14, 1837-1851 (2000). 3.Reya, T. and Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 834-850 (2005). 4.Chen, B.,Dodge, M.E.,Tang, W., et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology 5(2), 100-107 (2009). 5.Lian, X.,Hsiao, C.,Wilson, G., et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America E1848-E1857 (2012). 6.Mo, M.L.,Li, M.R.,Chen, Z., et al. Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/ß-catenin pathway in gastric cancer. Oncology Letters 5, 1719-1723 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 466.6 |
| 分子式 | C22H18N4O2S3 |
| CAS号 | 686770-61-6 |
| 稳定性 | ≥ 2 years |
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