| 货号 | 13876-10mg |
| 描述 | Alexidine is an alkyl bis(biguanide) antiseptic which has been used in mouthwashes to eliminate plaque forming microorganisms.1 It binds to lipopolysaccharide and lipoteichoic acid and inhibits fungal phospholipase B (IC50 ~ 250 nM).2,3 Alexidine also inhibits the mitochondrial phosphatase PTPMT1 (IC50 = 1.08 μM, in vitro) and induces apoptosis in cancer cell lines (ED50 = 1.8-2.6 μM).4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Coburn, R.A.,Baker, P.J.,Evans, R.T., et al. In vitro antiplaque properties of a series of alkyl bis(biguanides). Journal of Medicinal Chemistry 21(8), 828-829 (1978). 2.Zorko, M. and Jerala, R. Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics. Journal of Antimicrobial Chemotherapy 62, 730-737 (2008). 3.Ganendren, R.,Widmer, F.,Singhal, V., et al. In vitro antifungal activities of inhibitors of phospholipases from the fungal pathogen Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy 48(5), 1561-1569 (2004). 4.Doughty-Shenton, D.,Joseph, J.D.,Zhang, J., et al. Pharmacological targeting of the mitochondrial phosphatase PTPMT1. Journal of Pharmacology and Experimental Therapeutics 333(2), 584-592 (2010). 5.Yip, K.W.,Ito, E.,Mao, X., et al. Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Molecular Cancer Therapeutics 5(9), 2234-2240 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 581.7 |
| 分子式 | C26H56N10 • 2HCl |
| CAS号 | 1715-30-6 |
| 稳定性 | ≥ 2 years |
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