| 货号 | 13858-1mg |
| 描述 | Ceramides have diverse roles in cell differentiation, proliferation, and apoptosis.1,2 Ceramide kinase converts ceramide to ceramide-1-phosphate (C1P), removing the effects of ceramide in favor of those directed by C1P. NVP-231 is a potent, reversible inhibitor of ceramide kinase (IC50 = 12 nM).3 It has minimal effect on several other lipid kinases, including sphingosine kinases 1 and 2.3 In cells in which exogenous short chain ceramide is converted to C1P, resulting in cell death, NVP-231 prevents both C1P synthesis and cell death.4 In mouse dermal microvascular endothelial cells, where ceramide kinase increases capillary-like tube formation, NVP-231 (100 nM) inhibits C1P formation as well as tube formation.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Geilen, C.C.,Wieder, T. and Orfanos, C.E. Ceramide signalling: Regulatory role in cell proliferation, differentiation and apoptosis in human epidermis. Archives of Dermatological Research 289, 559-566 (1997). 2.Ballou, L.R.,Laulederkind, S.J.F.,Rosloniec, E.F., et al. Ceramide signalling and the immune response. Biochimica et Biophysica Acta 1301, 273-287 (1996). 3.Graf, C.,Klumpp, M.,Habig, M., et al. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Molecular Pharmacology 74(4), 925-932 (2008). 4.Graf, C.,Rovina, P. and Bornancin, F. A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Analytical Biochemistry 384(1), 166-169 (2009). 5.Niwa, S.,Graf, C. and Bornancin, F. Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 77(3), 389-393 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 431.6 |
| 分子式 | C25H25N3O2S |
| CAS号 | 362003-83-6 |
| 稳定性 | ≥ 2 years |
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