CAY10638
货号：
13695-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 13695-1mg |
| 描述 | Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.1 Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity.2,3 CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.3 |
| 别名 | Thiazolidinedione derivative; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review. Prostaglandins 12, 647-679 (1976).
2.Owens, D.R. Thiazolidinediones. An pharmacological overview. Clinical Drug Investigation 22(8), 485-505 (2002).
3.Wu, Y.,Tai, H.H. and Cho, H. Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors. Bioorganic & Medicinal Chemistry 18, 1428-1433 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 331.4 |
| 分子式 | C16H13NO3S2 |
| CAS号 | 1221413-57-5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
