| 货号 | 13693-1mg |
| 描述 | Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum.1 Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. It reduces the growth of the disease-causing parasites, L. mexicana and T. cruzi, in vitro(IC50s = 6.2 and 17.5 μM, respectively),2 inhibits influenza A replication (EC50s = 0.3-1 μM)3, and inhibits hepatitis B and hepatitis C virus replication (EC50s both = 0.15 μM).4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.de Carvalho, L.P.S.,Lin, G.,Jiang, X., et al. Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. Journal of Medicinal Chemistry 52, 5789-5792 (2009). 2.Chan-Bacab, M.J.,Hernández-Núñez, E. and Navarrete-Vázquez, G. Nitazoxanide, tizoxanide and a new analogue [4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide; NTB] inhibit the growth of kinetoplastid parasites (Trypanosoma cruzi and Leishmania mexicana) in vitro. Journal of Antimicrobial Chemotherapy 63(6), 1292-1293 (2009). 3.Rossignol, J.F.,La Frazia, S.,Chiappa, L., et al. Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level. The Journal of Biological Chemisty 284(43), 29798-29808 (2009). 4.Korba, B.E.,Montero, A.B.,Farrar, K., et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 77, 56-63 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 265.3 |
| 分子式 | C10H7N3O4S |
| CAS号 | 173903-47-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |