MLN8237
货号：
13602-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 13602-1mg |
| 描述 | MLN8237 is a selective inhibitor of Aurora A kinase (IC50s = 1 and 1,100 nM for Aurora A and B, respectively).1,2,3 At 20 mg/kg it inhibits tumor growth in nude mice bearing Calu-6 human lung tumor xenografts.1 MLN8237 has been evaluated for treatment of hematological malignancies or solid tumors in multiple phase II and III clinical trials.1 |
| 别名 | Alisertib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sells, T.B.,Chau, R.,Ecsedy, J.A., et al. MLN8054 and alisertib (MLN8237): Discovery of selective oral Aurora A inhibitors. ACS Med.Chem.Lett. (2015).
2.Pollard, J.R., and Mortimore, M. Discovery and development of Aurora kinase inhibitors as anticancer agents. Journal of Medicinal Chemistry 52(9), 2629-2651 (2009).
3.Gustafson, W.C.,Meyerowitz, J.G.,Nekritz, E.A., et al. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell 26(3), 414-427 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 518.9 |
| 分子式 | C27H20ClFN4O4 |
| CAS号 | 1028486-01-2 |
| 稳定性 | ≥ 2 years |
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