| 货号 | 13521-1mg |
| 描述 | Aconitase catalyzes the stereospecific isomerization of citrate to isocitrate in the first step of the citric acid cycle. It acts as an iron regulatory protein (IRP), controlling the translation of proteins involved in iron metabolism when iron is scarce and resumes aconitase activity when iron is abundant. Aconitase is now recognized as a regulator of iron-induced glutamate production.1 Oxalomalic acid, formed by the condensation of oxaloacetate with glyoxylate in vivo, inhibits both aconitase and NADP-dependent isocitrate dehydrogenase in the conversion of citrate to isocitrate at concentrations as low as 1 mM.2 At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gerber, D.E. EGFR inhibition in the treatment of non-small cell lung cancer. Drug Dev. Res. 69(6), 359-372 (2008). 2.Ruffo, A.,Testa, E.,Adinolfi, A., et al. Control of the citric acid cycle by glyoxylate. Mechanism of the inhibition by oxalomalate and γ-hydroxy-α-oxoglutarate. Biochemistry Journal 103, 19-23 (1967). 3.Festa, M.,Colonna, A.,Pietropaolo, C., et al. Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteins. Biochemistry Journal 348, 315-320 (2000). 4.McGahan, M.C.,Harned, J.,Mukunnemkeril, M., et al. Iron alters glutamate secretion by regulating cytosolic aconitase activity. American Journal of Physiology.Cell Physiology 288, 1117-1124 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 275 |
| 分子式 | C6H6O8 ?3Na |
| CAS号 | 89304-26-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |