| 货号 | 13352-5mg |
| 描述 | EHNA is a reversible adenosine deaminase inhibitor (IC50 = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC50s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet).1,2 Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC50s > 100 μM).1 EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.3,4,5 |
| 别名 | NSC 263164;erythro-9-(2-Hydroxy-3-nonyl)adenine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Podzuweit, T.,Nennstiel, P., and Müller, A. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine. Cellular Signalling 7(7), 733-738 (1995). 2.Michie, A.M.,Lobban, M.,Müller, T., et al. Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cellular Signalling 8(2), 97-110 (1996). 3.Barankiewicz, J.,Danks, A.M.,Abushanab, E., et al. Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors. Journal of Pharmacology and Experimental Therapeutics 283(3), 1230-1238 (1997). 4.Dickinson, N.T.,Jang, E.K., and Haslam, R.J. Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: Effects on platelet aggregation. Biochemistry Journal 323, 371-377 (1997). 5.Burton, P.,Adams, D.R.,Abraham, A., et al. Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochemistry Journal 432(3), 1-22 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 313.8 |
| 分子式 | C14H23N5O • HCl |
| CAS号 | 58337-38-5 |
| 稳定性 | ≥ 2 years |
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