KD 5170
货号：
13214-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 13214-1mg |
| 描述 | KD 5170 is a mercaptoketone-based inhibitor of class I and II histone deacetylases (HDACs; IC50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively).1 It exhibits broad spectrum antitumor activity in vitroandin vivo.1,2,3 KD 5170 increases the acetylation of histones and activates caspases 3, 8, and 9, leading to apoptosis in primary myeloma cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hassig, C.A.,Symons, K.T.,Guo, X., et al. KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Mol. Cancer Ther. 7(5), 1054-1065 (2008).
2.Feng, R.,Ma, H.,Hassig, C.A., et al. KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling. Mol. Cancer Ther. 7(6), 1494-1505 (2008).
3.Payne, J.E.,Bonnefous, C.,Hassig, C.A., et al. Identification of KD5170: A novel mercaptoketone-based histone deacetylase inhibitor. Bioorganic & Medicinal Chemistry Letters 18, 6093-6096 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 451.6 |
| 分子式 | C20H25N3O5S2 |
| CAS号 | 940943-37-3 |
| 稳定性 | ≥ 2 years |
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