PP2
货号：
13198-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 13198-1mg |
| 描述 | The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck(IC50 = 4 nM), p59fynT(IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM).1 PP2 does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 > 100 µM).1 PP2 inhibits the activation of focal adhesion kinase as well as its phosphorylation at Tyr577. PP2 also inhibits anti-CD3-stimulated tyrosine phosphorylation of human T-cells with an IC50 value of 600 nM.1 |
| 别名 | AGL 1879; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hanke, J.H.,Gardner, J.P.,Dow, R.L., et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. The Journal of Biological Chemisty 271(2), 695-701 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 301.8 |
| 分子式 | C15H16ClN5 |
| CAS号 | 172889-27-9 |
| 稳定性 | ≥ 2 years |
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