| 货号 | 13104-50mg |
| 描述 | Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals.1,2 It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA.3,4 DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.1 The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.2,5 |
| 别名 | Estreptozocin;NSC 37917;NSC 85998;STZ;U 9889;Zanosar; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Szkudelski, T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol.Res. 50, 536-546 (2001). 2.Leiter, E.H. Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymus. Proceedings of the National Academy of Sciences of the United States of America 79, 630-634 (1982). 3.Melmed, R.N.,Benitez, C.J., and Holt, S.J. Intermediate cells of the pancreas. III. Selective autophagy and destruction of β-granules in intermediate cells of the rat pancreas induced by alloxan and streptozotocin. Journal of Cell Science 13, 297-315 (1973). 4.Bennett, R.A., and Pegg, A.E. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Research 41, 2786-2790 (1981). 5.Kramer, J.,Moeller, E.L.,Hachey, A., et al. Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primates. American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 296, R786-R793 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 265.2 |
| 分子式 | C8H15N3O7 |
| CAS号 | 18883-66-4 |
| 稳定性 | ≥ 2 years |
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