| 货号 | 13033-10g |
| 描述 | Valproic acid is an analog of the natural fatty acid valeric acid. The sodium salt of valproic acid has long been used as an anticonvulsant to prevent many kinds of seizures. It is an inhibitor of histone deacetylases (HDACs), inhibiting Class I HDACs with an IC50 of ~2 mM.1 Valproic acid also inhibits glycogen synthase kinase 3 (GSK3) and depletes cellular inositol-1,4,5-trisphosphate (1,4,5-IP3).2 Because of these actions, valproic acid shows promise in combination therapy for cancer and in treating Alzheimer’s disease.3,4 Valproic acid (1 mM) also has pronounced effects on stem cell differentiation and self-renewal.5,6 |
| 别名 | 2-Propylvaleric Acid;Sodium Valproate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Göttlicher, M.,Minucci, S.,Zhu, P., et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO Journal 20(24), 6969-6978 (2001). 2.Williams, R.S.B.,Cheng, L.,Mudge, A.W., et al. A common mechanism of action for three mood-stabilizing drugs. Nature 417(6886), 292-295 (2002). 3.Noguchi, H.,Yamashita, H.,Murakami, T., et al. Successful treatment of anaplastic thyroid carcinoma with a combination of oral valproic acid, chemotherapy, radiation and surgery. Endocrine Journal 56(2), 245-249 (2009). 4.Qing, H.,He, G.,Ly, P.T.T., et al. Valproic acid inhibits Aβproduction, neuritic plaque formation, and behavioral deficits in Alzheimer’s disease mouse models. Journal of Experimental Medicine 205(12), 2781-2789 (2008). 5.Bug, G.,Gül, H.,Schwarz, K., et al. Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Research 65(7), 2537-2541 (2005). 6.Jung, G.A.,Yoon, J.Y.,Moon, B.S., et al. Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via theβcatenin-Ras-ERK-p21Cip/WAFI pathway. BMC Cell Biology 9(66), (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 166.2 |
| 分子式 | C8H15O2 • Na |
| CAS号 | 1069-66-5 |
| 稳定性 | ≥ 2 years |
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