| 货号 | 12088-25mg |
| 描述 | Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM).1,2,3 It blocks the transcription of genes involved in T cell activation by interfering with the calcineurin-driven nuclear import of the transcription factor NFAT.1,4,5 Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection.6 |
| 别名 | NSC 290193; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jorgensen, K.A.,Koefoed-Nielsen, P.B., and Karamperis, N. Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus. Scandinavian Journal of Immunology 57(2), 93-98 (2003). 2.Mrowietz, U. Macrolide immunosuppressants. Eur.J.Dermatol. 9(5), 346-351 (1999). 3.Fruman, D.A.,Klee, C.B.,Bierer, B.E., et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proceedings of the National Academy of Sciences of the United States of America 89(9), 3686-3690 (1992). 4.Roehrl, M.H.A.,Kang, S.,Aramburu, J., et al. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proceedings of the National Academy of Sciences of the United States of America 101(20), 7554-7559 (2004). 5.McCaffrey, P.G.,Perrino, B.A.,Soderling, T.R., et al. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. The Journal of Biological Chemisty 268(5), 3747-3752 (1993). 6.Laupacis, A.,Keown, P.A.,Ulan, R.A., et al. Cyclosporin A: A powerful immunosuppressant. Can.Med.Assoc.J. 126(9), 1041-1046 (1982). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 1202.6 |
| 分子式 | C62H111N11O12 |
| CAS号 | 59865-13-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |