| 货号 | 12072-1mg |
| 描述 | The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles.1,2,3 SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM).4 It is without effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor α. SR 3335 evokes RORα-dependent effects both in vitroandin vivo, altering gene expression as well as gluconeogenesis.4 |
| 别名 | ML 176; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Solt, L.A.,Kumar, N.,Nuhant, P., et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nat.Lett. 472(7344), 491-494 (2011). 2.Jetten, A.M., and Ueda, E. Retinoid-related orphan receptors (RORs): Roles in cell survival, differentiation and disease. Cell Death and Different 9(11), 1167-1171 (2002). 3.Ivanov, I.I.,McKenzie, B.S.,Zhou, L., et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121-1133 (2006). 4.Kumar, N.,Kojetin, D.J.,Solt, L.A., et al. Identification of SR3335 (ML176): A synthetic RORα selective inverse agonist. ACS Chemical Biology 6(3), 218-222 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 405.3 |
| 分子式 | C13H9F6NO3S2 |
| CAS号 | 293753-05-6 |
| 稳定性 | ≥ 2 years |
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