SR 1555 (hydrochloride)
货号：
12071-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 12071-1mg |
| 描述 | Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the development of TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.1,2 SR 1555 is a selective ligand of RORγ (IC50 = 1 μM).3 It does not bind RORα, LXR, or FXR. SR 1555 acts as an inverse agonist of RORγ, inhibiting endogenous IL-17A gene expression in mouse splenocytes and suppressing differentiation of TH17 cells when cultured under TH17 polarizing conditions.3 Moreover, SR 1555 stimulates T regulatory development when cultured under T regulatory polarizing conditions, unlike digoxin and ursolic acid.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ivanov, I.I.,McKenzie, B.S.,Zhou, L., et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121-1133 (2006).
2.Solt, L.A.,Kumar, N.,Nuhant, P., et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nat.Lett. 472(7344), 491-494 (2011).
3.Solt, L.A.,Kumar, N.,He, Y., et al. Identification of a selective RORγ ligand that suppresses TH17 cells and stimulates T regulatory cells. ACS Chemical Biology 7, 1515-1519 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 496.9 |
| 分子式 | C22H22F6N2O2 • HCl |
| 稳定性 | ≥ 2 years |
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