CP 945,598 (hydrochloride)
货号：
11955-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 11955-1mg |
| 描述 | CP 945,598 (hydrochloride) is a selective antagonist of the cannabinoid receptor CB1 with a Ki value of 0.7 nM and demonstrates relatively low affinity for CB2 receptors (Ki = 7.6 µM).1,2 It is reported to reverse cannabinoid agonist-mediated responses (i.e., hypo-locomotion, hypothermia, analgesia, and catalepsy), to reduce food intake, and to increase energy expenditure as well as fat oxidation in rats.1,2 |
| 别名 | Otenabant; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Griffith, D.A.,Hadcock, J.R.,Black, S.C., et al. Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J. Med. Chem. 52(2), 234-237 (2009).
2.Hadcock, J.R.,Griffith, D.A.,Iredale, P.A., et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochem. Biophys. Res. Commun. 394(2), 366-371 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 546.9 |
| 分子式 | C25H25Cl2N7O • HCl |
| CAS号 | 686347-12-6 |
| 稳定性 | ≥ 2 years |
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