SR 58611A (hydrochloride)
货号：
11954-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 11954-500ug |
| 描述 | SR 58611A is a selective β3-adrenergic receptor agonist (β3-AR; EC50 = 3.5 nM in rat colon).1 Its activity cannot be blocked by the β1- and β2-AR antagonists, CGP 20712A and ICI 118551 (Item No. 15591), respectively. SR 58611A is minimally active against β1-ARs in rat uterus (EC50 = 499 nM) and inactive against β2-ARs in guinea pig trachea and atrium (EC50s = >10,000 and >30,000 nM, respectively). SR 58611A activates brown fat metabolism through activation of adenylyl cyclase activity and glycerol release in brown adipocytes (EC50s = 20 and 11 nM, respectively).2 It also reduces hypothermia produced by apomorphine (Item No. 16094) and reserpine (Item No. 16474) and potentiates toxicity produced by yohimbine (Item No. 19869) in mice.3 SR 586611A (0.6 to 2 mg/kg/day) also reduces the number of escape failures in a learned helplessness model of antidepressant-like activity in rats without changes in locomotor activity typically seen with β2-AR agonists. |
| 别名 | Amibegron; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bianchetti, A., and Manara, L. In vitro inhibition of intestinal motility by phenylethanolaminotetralines: Evidence of atypical β-adrenoceptors in rat colon.. Br. J. Pharmacol. 100(4), 831-839 (1990).
2.Nisoli, E.,Tonello, C., and Carruba, M.O. SR 58611A: A novel thermogenic β-adrenoceptor agonist. Eur. J. Pharmacol. 259(2), 181-186 (1994).
3.Simiand, J.,Keane, P.E.,Guitard, J., et al. Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical β-adrenoceptors. Eur. J. Pharmacol. 219(2), 193-201 (1992).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 440.4 |
| 分子式 | C22H26ClNO4 • HCl |
| CAS号 | 121524-09-2 |
| 稳定性 | ≥ 2 years |
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