| 货号 | 11953-1mg |
| 描述 | SKF 86466 is a selective antagonist of α2-adrenoceptors that shows nanomolar Ki values for the three subtypes, α2A, α2B, and α2C.1,2 It is active in vivo, evoking antihypertensive effects in animal studies and clinical trials.3,2 SKF 86466 is used to study the role of α2-adrenoceptors in animals.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ruffolo, R.R., Jr.,Bondinell, W., and Hieble, J.P. α- and β-adrenoceptors: From the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J. Med. Chem. 38(19), 3681-3716 (1995). 2.Schafers, R.F.,Elliott, H.L.,Howie, C.A., et al. An evaluation of the α-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br. J. Clin. Pharmacol. 30(6), 884-888 (1990). 3.Roesler, J.M.,McCafferty, J.P.,DeMarinis, R.M., et al. Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J. Pharmacol. Exp. Ther. 236(1), 1-7 (1986). 4.Sáiz, J.,Pazos, A.,Del Olmo, E., et al. Yohimbine-induced alterations in α2-adrenoceptors in kidney regions of the spontaneously hypertensive rats: An autoradiographic analysis. Pharmacol. Rep. 60(3), 391-398 (2008). 5.Tanabe, M.,Hashimoto, M., and Ono, H. Imidazoline I1 receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson’s disease. Eur. J. Pharmacol. 589(1-3), 102-105 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 232.2 |
| 分子式 | C11H14ClN • HCl |
| CAS号 | 86129-54-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |