| 货号 | 11940-1mg |
| 描述 | KW 3902 is an antagonist of the adenosine A1 receptor (Ki = 0.19 nM).1,2 It displays 890-fold selectivity for A1 receptors over A2A receptors and has no activity at A3 receptors. KW 3902 less potently inhibits human organic anion transporter 1 (OAT1; Ki = 7.82 µM).3 KW 3902 exhibits renal protective effects during hypoxemia in rabbits.4 |
| 别名 | MK-7418;Rolofylline; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shimada, J.,Suzuki, F.,Nonaka, H., et al. 8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. J. Med. Chem. 35(5), 924-930 (1992). 2.Nonaka, H.,Ichimura, M.,Takeda, M., et al. KW-3902, a selective high affinity antagonist for adenosine A1 receptors. Br. J. Pharmacol. 117(8), 1645-1652 (1996). 3.Takeda, M.,Narikawa, S.,Hosoyamada, M., et al. Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. European Journal of Pharmacology 419(2-3), 113-120 (2001). 4.Nishiyama, A.,Miyatake, A.,Aki, Y., et al. Adenosine A1 receptor antagonist KW-3902 prevents hypoxia-induced renal vasoconstriction. J. Pharmacol. Exp. Ther. 291(3), 988-993 (1999). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.5 |
| 分子式 | C20H28N4O2 |
| CAS号 | 136199-02-5 |
| 稳定性 | ≥ 2 years |
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