| 货号 | 11904-1g |
| 描述 | Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals.1 Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes.2,3 It is also reported to inhibit the migration of hepatocarcinoma cells and render them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream, such as SOD, catalase, and glutathione peroxidase.4,5 |
| 别名 | N-methyl Nicotinic Acid betaine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nuhu, A.A. Bioactive micronutrients in coffee: Recent analytical approaches for characterization and quantification. ISRN Nutr. 2014:384230, (2014). 2.Yoshinari, O.,Sato, H., and Igarashi, K. Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Bioscience, Biotechnology, and Biochemistry 73(5), 1033-1041 (2009). 3.Aoyahi, R.,Funakoshi-Tago, M.,Fujiwara, Y., et al. Coffee inhibits adipocyte differentiation via inactivation of PPARγ. Biological and Pharmaceutical Bullentin 37(11), 1820-1825 (2014). 4.Liao, J.C.,Lee, K.T.,You, B.J., et al. Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration. Food Nutr.Res. 59:29884, (2015). 5.Arlt, A.,Sebens, S.,Krebs, S., et al. Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene 32(40), 4825-4835 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 173.6 |
| 分子式 | C7H8NO2 • Cl |
| CAS号 | 6138-41-6 |
| 稳定性 | ≥ 2 years |
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