18β-Glycyrrhetinic Acid
货号：
11845-1g 基本售价：
350.0 元 规格：
1 g
产品信息
概述| 货号 | 11845-1g |
| 描述 | 18β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Item No. 11847), one of the main constituents of licorice. Both 18β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory properties. 18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 μM).1 At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats.2 18β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC50 values of 16.1, 19.3, 15.8, and 13.7 μM, respectively.3 At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.3 |
| 别名 | Arthrodont;Biosone;Enoxolone;α-Glycyrrhetinic Acid;GM 1658;NSC 35347;PO 12;STX 352; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kroes, B.H.,Beukelman, C.J.,van den Berg, A.J.J., et al. Inhibition of human complement by β-glycyrrhetinic acid. Immunology 90, 115-120 (1997).
2.Kalaiarasi, P., and Pugalendi, K.V. Protective effect of 18β-glycyrrhetinic acid on lipid peroxidation and antioxidant enzymes in experimental diabetes. Journal of Pharmacy Research 4(1), 107-111 (2011).
3.Ishida, T.,Mizushina, Y.,Yagi, S., et al. Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities. Evidence-Based Complementary and alternative Medicine 2012, (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 470.7 |
| 分子式 | C30H46O4 |
| CAS号 | 471-53-4 |
| 稳定性 | ≥ 2 years |
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