| 货号 | 11807-1mg |
| 描述 | Catechin is a polyphenolic flavonoid that has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany.1,2 Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid peroxidation assays.3 (−)-Epicatechin is a 2R,3R stereoisomer of catechin. Like catechin, (−)-epicatechin is a powerful antioxidant.4 It inhibits cyclooxygenase 1 (IC50 = 3.2 μM).5 Also, at 100 µM, (−)-epicatechin induces apoptosis in human adenocarcinoma PC-9 cells and stimulates the inhibition of tumor necrosis factor-α release from BALB-c/3T3 cells treated with epigallocatechin gallate.6 |
| 别名 | epi-Catechin;NSC 81161; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bonilla, F.,Mayen, M.,Merida, J., et al. Extraction of phenolic compounds from red grape marc for use as food lipid antioxidants. Food Chemistry 66, 209-215 (1999). 2.Ravindranath, M.H.,Ramasamy, V.,Moon, S., et al. Differential growth suppression of human melanoma cells by tea (Camellia sinensis) epicatechins (ECG, EGC and EGCG). Evidence-Based Complementary and alternative Medicine 6(4), 523-530 (2009). 3.Zhao, J.,Wang, J.,Chen, Y., et al. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3-gallate as the most effective antioxidant constituent. Carcinogenesis 20, 1737-1745 (1999). 4.Xu, J.Z.,Yeung, S.Y.V.,Chang, Q., et al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. British Journal of Nutrition 91(6), 873-881 (2004). 5.Waffo-Téguo, P.,Hawthorne, M.E.,Cuendet, M., et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutrition and Cancer 40(2), 173-179 (2001). 6.Suganuma, M.,Okabe, S.,Kai, Y., et al. Synergisitc effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer Research 59(1), 44-47 (1999). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 290.3 |
| 分子式 | C15H14O6 |
| CAS号 | 490-46-0 |
| 稳定性 | ≥ 2 years |
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