| 货号 | 11785-5mg |
| 描述 | L-Homopropargyl glycine is a reactive methionine analog that contains an alkyne moiety. It is readily inserted into newly-synthesized proteins in place of methionine.1,2,3 L-Homopropargyl glycine can then be labeled or captured through click chemistry.2,4 This approach represents a fast, sensitive, and non-radioactive alternative to [35S]-methionine for the detection of nascent protein synthesis. |
| 别名 | Click Tag™ L-Homopropargyl Glycine;HPG; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beatty, K.E., and Tirrell, D.A. Two-color labeling of temporally defined protein populations in mammalian cells. Bioorganic & Medicinal Chemistry Letters 18(22), 5995-5999 (2008). 2.Ngo, J.T., and Tirrell, D.A. Non-canonical amino acids in the interrogation of cellular protein synthesis. Accounts of Chemical Research 44(9), 677-685 (2011). 3.Landgraf, P.,Antileo, E.R.,Schuman, E.M., et al. BONCAT: Metabolic labeling, click chemistry, and affinity purification of newly synthesized proteomes. Methods in Molecular Biology 1266, 199-215 (2015). 4.Dieterich, D.C.,Hodas, J.J.L.,Gouzer, G., et al. In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons. Nature Neuroscience 13(7), 897-905 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 127.1 |
| 分子式 | C6H9NO2 |
| CAS号 | 98891-36-2 |
| 稳定性 | ≥ 2 years |
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