| 货号 | 11682-5mg |
| 描述 | The asarones, including α-asarone (Item No. 11681) and β-asarone, were first isolated from volatile oils of plants of the genus Acorus, which are used in Ayurvedic medicine. β-Asarone is noted for its neuroprotective effects, as it ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates damage in a model of stroke.1,2,3 In isolated neurons and in brains, β-asarone blocks autophagy, reduces inflammation, and inhibits apoptosis.2,3,4 While β-asarone inhibits apoptosis in neurons, it induces apoptosis in colon cancer cells.5 It also has antimicrobial effects.6 |
| 别名 | cis-Asarone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sun, Y.R.,Wang, X.Y.,Li, S.S., et al. β-Asarone from Acorus gramineus alleviates depression by modulating MKP-1. Genet.Mol.Res. 14, 4495-4504 (2015). 2.Zhang, S.,Gui, X.H.,Huang, L.P., et al. Neuroprotective effects of β-asarone against 6-hydroxy dopamine-induced parkinsonism via JNK/Bcl-2/Beclin-1 Pathway. Mol.Neurobiol. (2014). 3.Yang, Y.X.,Chen, Y.T.,Zhou, X.J., et al. Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats. BMC Complement.Altern.Med. 13, (2013). 4.Wei, G.,Chen, Y.B.,Chen, D.F., et al. β-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AβPP/PS1 mice. J.Alzheimers Dis. 33, 863-880 (2013). 5.Zou, X.,Liu, S.L.,Zhou, J.Y., et al. β-Asarone induces LoVo colon cancer cell apoptosis by up-regulation of caspases through a mitochondrial pathway in vitro and in vivo. Asian Pac.J.Cancer Prev. 13(10), 5291-5298 (2012). 6.Rajput, S.B., and Karuppayil, S.M. β-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans. Phytomedicine 20, 139-142 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 208.3 |
| 分子式 | C12H16O3 |
| CAS号 | 5273-86-9 |
| 稳定性 | ≥ 1 year |
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