| 货号 | 11677-10mg |
| 描述 | Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.1 It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.2,3 Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.4,5 |
| 别名 | 3-Hydroxymethylchrysazine;NSC 38628;Rhabarberone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Xu, J.D.,Liu, S.,Wang, W., et al. Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons. British Journal of Pharmacology 165(1), 197-207 (2012). 2.Xie, M.J.,Ma, Y.H.,Miao, L., et al. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway. Asian Pac.J.Cancer Prev. 15(13), 5201-5205 (2014). 3.Pecere, T.,Gazzola, M.V.,Mucignat, C., et al. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Research 60(11), 2800-2804 (2000). 4.Matsuda, H.,Shimoda, H.,Morikawa, T., et al. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): Structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorganic & Medicinal Chemistry Letters 11(14), 1839-1842 (2001). 5.Huang, P.H.,Huang, C.Y.,Chen, M.C., et al. Emodin and aloe-emodin suppress breast cancer cell proliferation through ERα inhibition. Evidence-Based Complementary and alternative Medicine 2013, 1-12 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 270.2 |
| 分子式 | C15H10O5 |
| CAS号 | 481-72-1 |
| 稳定性 | ≥ 2 years |
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