| 货号 | 11614-10mg |
| 描述 | Angiotensin II is a peptide hormone which regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure.1 Olmesartan Medoxomil is a prodrug that is metabolized in vivo to RNH-6270, a nonpeptide angiotensin II antagonist that potently inhibits angiotensin binding to the AT1 receptor (IC50 = 7.7 nM) without affecting binding to the AT2receptor.2 Through this action, olmesartan medoxomil reduces blood pressure, and thereby indirectly improves several cardiovascular parameters.3,4,5,6 |
| 别名 | Benicar;CS 866;Olmetec; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Frampton, J.E. Telmisartan: A review of its use in cardiovascular disease prevention. Drugs 71, 651-677 (2011). 2.Mizuno, M.,Sada, T.,Ikeda, M., et al. Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. European Journal of Pharmacology 285, 181-188 (1995). 3.Fraisse, L.,Bonnet, M.C.,de Farcy, J.P., et al. A colorimetric 96-well microtiter plate assay for the determination of urate oxidase activity and its kinetic parameters. Analytical Biochemistry 309, 173-179 (2002). 4.Warner, G.T., and Jarvis, B. Olmesartan medoxomil. Drugs 62(9), 1345-1353 (2002). 5.Brunner, H.R. The new oral angiotensin II antagonist olmesartan medoxomil: a concise overview. Journal of Human Hypertension 16, S13-S16 (2002). 6.Mason, R.P. Optimal therapeutic strategy for treating patients with hypertension and atherosclerosis: focus on olmesartan medoxomil. Vascular Health and Risk Management 7, 405-416 (2011). | |
| 运输条件 | Wet Ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 558.6 |
| 分子式 | C29H30N6O6 |
| CAS号 | 144689-63-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |