| 货号 | 11571-5mg |
| 描述 | Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50 = 28, 25, and 20 nM for RXRα, β, and γ, respectively).1 It inhibits cell cycle progression, induces apoptosis, prevents or overcomes multidrug resistance through multidrug resistance protein 1 (MDR1), and blocks angiogenesis and metastasis, making it a promising chemopreventive agent against cancer.2,3 Bexarotene also, through RXR activation, stimulates clearance of soluble β-amyloid, reduces plaque area, and reverses deficits related to Alzheimer’s disease in mice.4 |
| 别名 | LG 100069;LGD 1069;Ro 26-4455;SR 11247;Targretin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Boehm, M.F.,Zhang, L.,Zhi, L., et al. Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. Journal of Medicinal Chemistry 38, 3146-3155 (1995). 2.Bischoff, E.D.,Gottardis, M.M.,Moon, T.E., et al. Beyond tamoxifen: The retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma. Cancer Research 58, 479-484 (1998). 3.Qu, L. and Tang, X. Bexarotene: A promising anticancer agent. Cancer Chemotherapy and Pharmacology 65, 201-205 (2010). 4.Cramer, P.E.,Cirrito, J.R.,Wesson, D.W., et al. ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science 335, 1503-1506 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.5 |
| 分子式 | C24H28O2 |
| CAS号 | 153559-49-0 |
| 稳定性 | ≥ 2 years |
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