CHR-6494
货号：
11478-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 11478-1mg |
| 描述 | CHR-6494 is a haspin protein kinase inhibitor (IC50 = 2 nM) selective over 27 other protein kinases, including Aurora B kinase (IC50 > 1 µM). Haspin is a kinase necessary for mitosis that selectively phosphorylates histone 3 at the threonine 3 residue (H3T3ph).1 CHR-6494 decreases phosphorylation of H3T3 and arrests the cell cycle in the G2/M phase, which leads to apoptosis. It showed promising results in a xenograft tumor model. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huertas, D.,Soler, M.,Moreto, J., et al. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 1-11 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 292.3 |
| 分子式 | C16H16N6 |
| CAS号 | 1333377-65-3 |
| 稳定性 | ≥ 2 years |
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