| 货号 | 11314-1mg |
| 描述 | Chelerythrine (chloride) is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase.1 Chelerythrine also inhibits BclXL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines.2 Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitroandin vivo.3,4,5,6 |
| 别名 | Broussonpapyrine chloride;NSC 646662; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Herbert, J.M.,Augereau, J.M.,Gleye, J., et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochemical and Biophysical Research Communications 172, 993-999 (1990). 2.Chan, S.L.,Lee, M.C.,Tan, K.O., et al. Identification of chelerythrine as an inhibitor of BclXL function. The Journal of Biological Chemisty 278(23), 20453-20456 (2003). 3.Lee, S.K.,Qing, W.G.,Mar, W., et al. Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. The Journal of Biological Chemisty 273(31), 19829-19833 (1998). 4.Chmura, S.J.,Dolan, M.E.,Cha, A., et al. In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clinical Cancer Research 6, 737-742 (2012). 5.Yu, R.,Mandlekar, S.,Tan, T.H., et al. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. The Journal of Biological Chemisty 275(13), 9612-9619 (2000). 6.Zhang, Z.F.,Guo, Y.,Zhang, J.b., et al. Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell. Archives of Pharmacal Research 34(5), 791-800 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 383.8 |
| 分子式 | C21H18NO4 • Cl |
| CAS号 | 3895-92-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |