Anisomycin
货号：
11308-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 11308-5mg |
| 描述 | Anisomycin is a pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis.1 It activates stress-activated protein kinase, MAP kinase, and other signal transduction pathways. At 30 mg/kg, anisomycin displays immunosuppressive activity superior to that of Cyclosporine A, blocking T cell proliferation in skin-transplanted mice.2 Through a caspase-8-dependent pathway, anisomycin acts as a potent and specific anoikis sensitizer of malignant epithelial cells resistant to apoptosis upon detachment from the ECM, preventing distal tumor formation in a mouse model of prostate cancer metastases.3 |
| 别名 | Flagecidin;NSC 76712;Wuningmeisu C; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Grollman, A.P. Inhibitors of protein biosynthesis. The Journal of Biological Chemisty 242(13), 3226-3233 (1967).
2.Xing, F.,Yu, Z.,Liu, J., et al. Anisomycin inhibits the behaviors of T cells and the allogeneic skin transplantation in mice. J.Immunother. 31, 858-870 (2008).
3.Mawji, I.A.,Simpson, C.D.,Gronda, M., et al. A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Research 67, 8307-8315 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 265.3 |
| 分子式 | C14H19NO4 |
| CAS号 | 22862-76-6 |
| 稳定性 | ≥ 2 years |
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