| 货号 | 11158-100mg |
| 描述 | Diphenhydramine (DPH) is a first generation antihistamine which is a potent antagonist of the human H1 receptor (Ki = 11.7 nM).1,2 Like many first generation antihistamines, DPH readily crosses the blood-brain barrier and produces diverse cognitive and psychomotor effects.3,1 DPH also antagonizes muscarinic cholinergic receptors (Ki = 100 to 260 nM for M1 through M5), increasing the range of central nervous system effects and applications.4 |
| 别名 | DPH; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Thurmond, R.L.,Gelfand, E.W. and Dunford, P.J. The role of histamine H1 and H4 receptors in allergic inflammation: The search for new antihistamines. Nature Reviews.Drug Discovery 7, 41-53 (2008). 2.Booth, R.G.,Moniri, N.H.,Bakker, R.A., et al. A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H1 receptors. Journal of Pharmacology and Experimental Therapeutics 302(1), 328-336 (2002). 3.Kay, G.G. and Harris, A.G. Loratadine: A non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clinical and Experimental Allergy 29, 147-150 (1999). 4.Bolden, C.,Cusack, B. and Richelson, E. Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. Journal of Pharmacology and Experimental Therapeutics 260, 576-580 (1992). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 291.8 |
| 分子式 | C17H21NO • HCl |
| CAS号 | 147-24-0 |
| 稳定性 | ≥ 2 years |
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