HA-155
货号：
11034-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 11034-1mg |
| 描述 | Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. HA-155 is a boronic acid-based compound that inhibits autotaxin (IC50 = 5.7 nM) by selectively binding to its catalytic threonine.1,2 It has been shown to dose-dependently block thrombin-induced LPA secretion in platelets.3 |
| 别名 | Autotaxin Inhibitor IV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hausmann, J.,Kamtekar, S.,Christodoulou, E., et al. Structural basis of substrate discrimination and integrin binding by autotaxin. Nature Structural & Molecular Biology 18(2), 198-204 (2011).
2.Albers, H.M.H.G.,Hendrickx, L.J.D.,van Tol, R.J.P., et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. Journal of Medicinal Chemistry 54(13), 4619-4626 (2011).
3.Fulkerson, Z.,Wu, T.,Sunkara, M., et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. The Journal of Biological Chemisty 286(40), 34654-34663 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 463.3 |
| 分子式 | C24H19BFNO5S |
| CAS号 | 1229652-22-5 |
| 稳定性 | ≥ 2 years |
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