CCG-50014
货号：
10802-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10802-1mg |
| 描述 | CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins.1 RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins.1 CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα0, while blocking GTPase activity and Gα0-dependent translocation of RGS4 to the membrane.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Blazer, L.L.,Zhang, H.,Casey, E.M., et al. A nanomolar-potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins. Biochemistry 50(15), 3181-3192 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 316.3 |
| 分子式 | C16H13FN2O2S |
| CAS号 | 883050-24-6 |
| 稳定性 | ≥ 2 years |
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