SC 26196
货号：
10792-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10792-1mg |
| 描述 | The enzyme Δ6 desaturase mediates the conversion of linoleic acid to γ-linolenic acid (GLA), which can then be elongated to dihomo-γ-linolenic acid (DGLA). DGLA can then be used as a substrate for Δ5 desaturase to produce arachidonic acid (AA), the fatty acid that is used to generate eicosanoids. SC 26196 is an inhibitor of Δ6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA).1 It is selective for Δ6 desaturase, as IC50 values for Δ5 and Δ9 desaturases exceed 200 µM and it has no effect on the conversion of dihomo-γ-linolenic acid to AA.1,2 SC 26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.1 It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.3 |
| 别名 | α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Obukowicz, M.G.,Welsch, D.J.,Salsgiver, W.J., et al. Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. Journal of Pharmacology and Experimental Therapeutics 287(1), 157-166 (1998).
2.Harmon, S.D.,Kaduce, T.L.,Manuel, T.D., et al. Effect of the Δ6-desaturase inhibitor SC-26196 on PUFA metabolism in human cells. Lipids 38(4), 469-476 (2003).
3.Mulligan, C.M.,Le, C.H.,deMooy, A.B., et al. Inhibition of Δ-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function. Journals of Gerontology.Series A, Biological Sciences and Medical Sciences 69(7), 799-809 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 423.6 |
| 分子式 | C27H29N5 |
| CAS号 | 218136-59-5 |
| 稳定性 | ≥ 2 years |
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