| 货号 | 10676-1mg |
| 描述 | The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, affect inflammatory gene expression by controlling the assembly of histone acetylation-dependent chromatin complexes.1,2 I-BET762 is a synthetic compound which interacts with BET proteins with high-affinity (Kd = 32.5-42.5 nM).3,4 It blocks binding of BET proteins with acetylated histones, disrupting the formation of chromatin complexes involved in the expression of specific inflammatory genes in activated macrophages.3 Through these actions, I-BET762 provides protection against bacteria-induced sepsis and lipopolysaccharide-triggered endotoxic shock.3 |
| 别名 | GSK525762A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.LeRoy, G.,Rickards, B. and Flint, S.J. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Molecular Cell 30(1), 51-60 (2008). 2.Hargreaves, D.C.,Horng, T. and Medzhitov, R. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138(1), 129-145 (2009). 3.Nicodeme, E.,Jeffrey, K.L.,Schaefer, U., et al. Suppression of inflammation by a synthetic histone mimic. Nature 468(7327), 1119-1123 (2010). 4.Dawson, M.A.,Kouzarides, T. and Huntly, B.J. Targeting epigenetic readers in cancer. N. Engl. J. Med. 367(7), 647-657 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 423.9 |
| 分子式 | C22H22ClN5O2 |
| CAS号 | 1260907-17-2 |
| 稳定性 | ≥ 1 year |
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