AS-1269574
货号：
10626-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10626-1mg |
| 描述 | GPR119, a glucose-dependent insulinotropic receptor, is a Gs protein-coupled receptor that is expressed in pancreas β-cells and intestinal L-cells.1 Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine and oleoyl ethanolamide increases intracellular cAMP levels and promotes glucose-stimulated insulin secretion.1,2 AS-1269574 is an agonist of GPR119 that is effective both in isolated cells and in vivo.3 It increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 μM) and glucose-stimulated insulin secretion in mice (100 mg/kg).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Overton, H.A.,Babbs, A.J.,Doel, S.M., et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metabolism 3, 167-175 (2006).
2.Soga, T.,Ohishi, T.,Matsui, T., et al. Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochemical and Biophysical Research Communications 326, 744-751 (2005).
3.Yoshida, S.,Ohishi, T.,Matsui, T., et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochemical and Biophysical Research Communications 400, 437-441 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 308.2 |
| 分子式 | C13H14BrN3O |
| CAS号 | 330981-72-1 |
| 稳定性 | ≥ 1 year |
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