Tubastatin A (trifluoroacetate salt)
货号：
10559-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10559-1mg |
| 描述 | Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.1 Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM).1 Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Butler, K.V.,Kalin, J.,Brochier, C., et al. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin A. Journal of the American Chemical Society 132(31), 10842-10846 (2010).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 449.4 |
| 分子式 | C20H21N3O2 • CF3COOH |
| CAS号 | 1239262-52-2 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
